EXPERT PANEL REPORT: Evaluation of the Current Validation Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants (March 2005) III. Bovine Corneal Opacity and Permeability Test Method
نویسندگان
چکیده
Page 57 § 1.1.2.: it is mentioned that some materials can cause serious corneal injury without appearing to change opacity or permeability immediately (e.g. mustard gas). Is this a specific observation for mustard gas or are other examples (agents) known which can induce damage without changes in opacity and/or permeability? Injury (cell death) without any change in opacity and/or permeability is very rare.
منابع مشابه
The bovine corneal opacity and permeability test in routine ocular irritation testing and its improvement within the limits of OECD test guideline 437.
Data on eye irritation are generally needed for the hazard identification of chemicals. As the Bovine Corneal Opacity and Permeability (BCOP) test has been accepted by many regulatory agencies for the identification of corrosive and severe ocular irritants since September 2009 (OECD Test Guideline 437, TG 437), we evaluated this alternative method for routine testing at BASF. We demonstrated ou...
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